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However, unlike propranolol, which nonspecifically blocks beta-1 and beta-2 adrenoreceptors, or atenolol, which has more affinity for the beta-1 adrenoreceptor but at higher doses loses its beta-1 specificity, nebivolol has an even higher affinity for the beta-1 adrenoreceptor.

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This interaction is most likely due to first-pass metabolic interaction between rizatriptan and propranolol.

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The dose of maxalt rdp should be adjusted in propranolol-treated patients, as propranolol has been shown to increase the plasma auc of maxalt rdp by 70 .

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However, in neither of these initial small studies in individuals without developmental diagnoses did the improvement with propranolol as compared to placebo reach significance.

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